An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope.
The HLA-B27-restricted HIV gag cytotoxic T-lymphocyte (CTL) epitope, 265-279, is highly conserved amongst HIV-1 isolates, only one, HIV-1ELI, having a single amino acid substitution. Over the same region HIV-2 differs by five amino acids. As a broadly cross-protective AIDS vaccine should protect aga...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1990
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| _version_ | 1797080027510079488 |
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| author | Nixon, D Huet, S Rothbard, J Kieny, M Delchambre, M Thiriart, C Rizza, C Gotch, F Mcmichael, A |
| author_facet | Nixon, D Huet, S Rothbard, J Kieny, M Delchambre, M Thiriart, C Rizza, C Gotch, F Mcmichael, A |
| author_sort | Nixon, D |
| collection | OXFORD |
| description | The HLA-B27-restricted HIV gag cytotoxic T-lymphocyte (CTL) epitope, 265-279, is highly conserved amongst HIV-1 isolates, only one, HIV-1ELI, having a single amino acid substitution. Over the same region HIV-2 differs by five amino acids. As a broadly cross-protective AIDS vaccine should protect against infection from all isolates of HIV-1 and HIV-2, we tested CTL specific for the HIV-1 265-279 epitope with peptide analogues from HIV-1ELI, HIV-2 and two simian immunodeficiency virus (SIV) isolates, and with recombinant vaccinia viruses expressing the respective gag genes, to determine whether there was any cross-reactivity for this CTL epitope. CTL from the HIV-1-infected donor could recognize the HIV-1ELI peptide, the HIV-2 peptide and recombinant vaccinia virus-infected target and one of the two SIV peptide-treated targets. Epitopes that exhibit such cross-reactivity may be valuable in vaccine design. |
| first_indexed | 2024-03-07T00:54:15Z |
| format | Journal article |
| id | oxford-uuid:877b31ba-cc35-4b51-9826-11ede3aa67f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:54:15Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:877b31ba-cc35-4b51-9826-11ede3aa67f12022-03-26T22:10:57ZAn HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:877b31ba-cc35-4b51-9826-11ede3aa67f1EnglishSymplectic Elements at Oxford1990Nixon, DHuet, SRothbard, JKieny, MDelchambre, MThiriart, CRizza, CGotch, FMcmichael, AThe HLA-B27-restricted HIV gag cytotoxic T-lymphocyte (CTL) epitope, 265-279, is highly conserved amongst HIV-1 isolates, only one, HIV-1ELI, having a single amino acid substitution. Over the same region HIV-2 differs by five amino acids. As a broadly cross-protective AIDS vaccine should protect against infection from all isolates of HIV-1 and HIV-2, we tested CTL specific for the HIV-1 265-279 epitope with peptide analogues from HIV-1ELI, HIV-2 and two simian immunodeficiency virus (SIV) isolates, and with recombinant vaccinia viruses expressing the respective gag genes, to determine whether there was any cross-reactivity for this CTL epitope. CTL from the HIV-1-infected donor could recognize the HIV-1ELI peptide, the HIV-2 peptide and recombinant vaccinia virus-infected target and one of the two SIV peptide-treated targets. Epitopes that exhibit such cross-reactivity may be valuable in vaccine design. |
| spellingShingle | Nixon, D Huet, S Rothbard, J Kieny, M Delchambre, M Thiriart, C Rizza, C Gotch, F Mcmichael, A An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. |
| title | An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. |
| title_full | An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. |
| title_fullStr | An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. |
| title_full_unstemmed | An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. |
| title_short | An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. |
| title_sort | hiv 1 and hiv 2 cross reactive cytotoxic t cell epitope |
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