Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.

Бусад хувилбаруудыг харуулах (1)

ATP-sensitive potassium (K(ATP)) channels are expressed in various tissues and cell-types where they act as so-called metabolic sensors that couple metabolic state to cellular excitability. The pore of most K(ATP) channel types is built by Kir6.2 subunits. Analysis of a general Kir6.2 knockout (KO)...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Deacon, R, Brook, R, Meyer, D, Haeckel, O, Ashcroft, F, Miki, T, Seino, S, Liss, B
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2006

Ижил төстэй зүйлс

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
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Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
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Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
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The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
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Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
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Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
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Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
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A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
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The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
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Хэвлэсэн: (2007)

The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
-н: Tammaro, P, зэрэг
Хэвлэсэн: (2007)

Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
-н: Ashcroft, F, зэрэг
Хэвлэсэн: (2001)

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
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Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
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A novel SUR1/Kir6.2 specific K-ATP channel opener
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Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
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Хэвлэсэн: (2001)

Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
-н: Hansen, A, зэрэг
Хэвлэсэн: (2005)

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
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Хэвлэсэн: (1999)

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.
-н: Gribble, F, зэрэг
Хэвлэсэн: (2000)

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
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Mapping the architecture of the ATP-binding site of Kir6.2
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Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
-н: Gloyn, A, зэрэг
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Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
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Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney
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Хэвлэсэн: (2009-06-01)

Identification of residues contributing to the ATP binding site of Kir6.2.
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ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer.
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A mouse model of neonatal diabetes caused by the K-ATP channel mutation Kir6.2-V59M
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Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.
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Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K+ channels
-н: Benjamin A. Heitz, зэрэг
Хэвлэсэн: (2021-11-01)

Functional coupling between Kir6.2 and SUR1 is prerequisite for [H-3]repaglinide, but not [H-3]glibenclamide, binding to pancreatic ATP-sensitive potassium (K-ATP) channels.
-н: Hansen, A, зэрэг
Хэвлэсэн: (2003)

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.
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Phentolamine block of KATP channels is mediated by Kir6.2.
-н: Proks, P, зэрэг
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Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
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Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
-н: Capener, C, зэрэг
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Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
-н: Gribble, F, зэрэг
Хэвлэсэн: (1998)

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
-н: Tammaro, P, зэрэг
Хэвлэсэн: (2007)

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.
-н: Ashfield, R, зэрэг
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ATP-dependent interaction of the cytosolic domains of Kir6.2 revealed by fluorescence resonance energy transfer
-н: Tsuboi, T, зэрэг
Хэвлэсэн: (2003)

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).
-н: Gloyn, A, зэрэг
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