Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by mutations in the Krebs cycle enzyme fumarate hydratase (FH). It has been proposed that "pseudohypoxic" stabilization of hypoxia-inducible factor-α (HIF-α) by fumarate accumulation contributes to tumorigenesis in HLRCC....

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Main Authors: Ashrafian, H, O'Flaherty, L, Adam, J, Steeples, V, Chung, Y, East, P, Vanharanta, S, Lehtonen, H, Nye, E, Hatipoglu, E, Miranda, M, Howarth, K, Shukla, D, Troy, H, Griffiths, J, Spencer-Dene, B, Yusuf, M, Volpi, E, Maxwell, P, Stamp, G, Poulsom, R, Pugh, C, Costa, B, Bardella, C, Di Renzo, M
Format: Journal article
Language:English
Published: 2010

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