Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.
The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extrac...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1826283165249961984 |
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| author | Kieffer, B Driscoll, P Campbell, I Willis, A Van Der Merwe, P Davis, S |
| author_facet | Kieffer, B Driscoll, P Campbell, I Willis, A Van Der Merwe, P Davis, S |
| author_sort | Kieffer, B |
| collection | OXFORD |
| description | The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extracellular region of the molecule (residues 1-70 of the mature protein; sCD59) has been solved by 2D NMR methods. sCD59 is a relatively flat, disk-shaped molecule consisting of a two-standed beta-sheet finger loosely packed against a protein core formed by a three-stranded beta-sheet and a short helix. Structure calculations allowed an unambiguous assignment of the disulfide-bonded cysteine pairs as 3-26, 6-13, 19-39, 45-63, and 64-69. The topology of sCD59 is similar to that of the snake venom neurotoxins and consistent with an evolutionary relationship existing between the Ly6SF and the neurotoxins. |
| first_indexed | 2024-03-07T00:54:48Z |
| format | Journal article |
| id | oxford-uuid:87ac9a58-b0e0-4ccf-b292-c222057948e9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:54:48Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:87ac9a58-b0e0-4ccf-b292-c222057948e92022-03-26T22:12:08ZThree-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:87ac9a58-b0e0-4ccf-b292-c222057948e9EnglishSymplectic Elements at Oxford1994Kieffer, BDriscoll, PCampbell, IWillis, AVan Der Merwe, PDavis, SThe cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extracellular region of the molecule (residues 1-70 of the mature protein; sCD59) has been solved by 2D NMR methods. sCD59 is a relatively flat, disk-shaped molecule consisting of a two-standed beta-sheet finger loosely packed against a protein core formed by a three-stranded beta-sheet and a short helix. Structure calculations allowed an unambiguous assignment of the disulfide-bonded cysteine pairs as 3-26, 6-13, 19-39, 45-63, and 64-69. The topology of sCD59 is similar to that of the snake venom neurotoxins and consistent with an evolutionary relationship existing between the Ly6SF and the neurotoxins. |
| spellingShingle | Kieffer, B Driscoll, P Campbell, I Willis, A Van Der Merwe, P Davis, S Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. |
| title | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. |
| title_full | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. |
| title_fullStr | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. |
| title_full_unstemmed | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. |
| title_short | Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. |
| title_sort | three dimensional solution structure of the extracellular region of the complement regulatory protein cd59 a new cell surface protein domain related to snake venom neurotoxins |
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