The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy
<p><strong>Background:</strong><br /> Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2020
|
| _version_ | 1826283187505987584 |
|---|---|
| author | Annink, KV de Vries, LS Groenendaal, F Vijlbrief, DC Weeke, LC Roehr, CC Lequin, M Reiss, I Govaert, P Benders, MJNL Dudink, J |
| author_facet | Annink, KV de Vries, LS Groenendaal, F Vijlbrief, DC Weeke, LC Roehr, CC Lequin, M Reiss, I Govaert, P Benders, MJNL Dudink, J |
| author_sort | Annink, KV |
| collection | OXFORD |
| description | <p><strong>Background:</strong><br />
Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed.</p><br />
<p><strong>Methods:</strong><br />
(Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3–7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3–7 were related to adverse outcome in univariate and the CUS of day 3–7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II).</p><br />
<p><strong>Results:</strong><br />
Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5–4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7–4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89).</p><br />
<p><strong>Conclusion:</strong><br />
This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.</p> |
| first_indexed | 2024-03-07T00:55:08Z |
| format | Journal article |
| id | oxford-uuid:87cc624e-126c-4309-be9a-a272d8b55782 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:55:08Z |
| publishDate | 2020 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:87cc624e-126c-4309-be9a-a272d8b557822022-03-26T22:12:56ZThe development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:87cc624e-126c-4309-be9a-a272d8b55782EnglishSymplectic ElementsSpringer Nature2020Annink, KVde Vries, LSGroenendaal, FVijlbrief, DCWeeke, LCRoehr, CCLequin, MReiss, IGovaert, PBenders, MJNLDudink, J<p><strong>Background:</strong><br /> Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed.</p><br /> <p><strong>Methods:</strong><br /> (Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3–7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3–7 were related to adverse outcome in univariate and the CUS of day 3–7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II).</p><br /> <p><strong>Results:</strong><br /> Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5–4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7–4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89).</p><br /> <p><strong>Conclusion:</strong><br /> This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.</p> |
| spellingShingle | Annink, KV de Vries, LS Groenendaal, F Vijlbrief, DC Weeke, LC Roehr, CC Lequin, M Reiss, I Govaert, P Benders, MJNL Dudink, J The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy |
| title | The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy |
| title_full | The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy |
| title_fullStr | The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy |
| title_full_unstemmed | The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy |
| title_short | The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy |
| title_sort | development and validation of a cerebral ultrasound scoring system for infants with hypoxic ischaemic encephalopathy |
| work_keys_str_mv | AT anninkkv thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT devriesls thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT groenendaalf thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT vijlbriefdc thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT weekelc thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT roehrcc thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT lequinm thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT reissi thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT govaertp thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT bendersmjnl thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT dudinkj thedevelopmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT anninkkv developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT devriesls developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT groenendaalf developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT vijlbriefdc developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT weekelc developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT roehrcc developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT lequinm developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT reissi developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT govaertp developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT bendersmjnl developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy AT dudinkj developmentandvalidationofacerebralultrasoundscoringsystemforinfantswithhypoxicischaemicencephalopathy |