Circadian clock regulation of hepatic energy metabolism regulatory circuits
The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particula...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2019
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| _version_ | 1797080091323269120 |
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| author | Hunter, A Ray, D |
| author_facet | Hunter, A Ray, D |
| author_sort | Hunter, A |
| collection | OXFORD |
| description | The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression. |
| first_indexed | 2024-03-07T00:55:11Z |
| format | Journal article |
| id | oxford-uuid:87d36760-b800-424a-a489-11792e768931 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:55:11Z |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:87d36760-b800-424a-a489-11792e7689312022-03-26T22:13:03ZCircadian clock regulation of hepatic energy metabolism regulatory circuitsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:87d36760-b800-424a-a489-11792e768931EnglishSymplectic Elements at OxfordMDPI2019Hunter, ARay, DThe liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression. |
| spellingShingle | Hunter, A Ray, D Circadian clock regulation of hepatic energy metabolism regulatory circuits |
| title | Circadian clock regulation of hepatic energy metabolism regulatory circuits |
| title_full | Circadian clock regulation of hepatic energy metabolism regulatory circuits |
| title_fullStr | Circadian clock regulation of hepatic energy metabolism regulatory circuits |
| title_full_unstemmed | Circadian clock regulation of hepatic energy metabolism regulatory circuits |
| title_short | Circadian clock regulation of hepatic energy metabolism regulatory circuits |
| title_sort | circadian clock regulation of hepatic energy metabolism regulatory circuits |
| work_keys_str_mv | AT huntera circadianclockregulationofhepaticenergymetabolismregulatorycircuits AT rayd circadianclockregulationofhepaticenergymetabolismregulatorycircuits |