Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

Expression of interleukin (IL)-4 is increased in tuberculosis and thought to be detrimental. We show here that in healthy contacts there is increased expression of its naturally occurring antagonist, IL-4delta2 (IL-4delta2). We identified contacts by showing that their peripheral blood mononuclear c...

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Détails bibliographiques
Auteurs principaux: Fletcher, H, Owiafe, P, Jeffries, D, Hill, P, Rook, G, Zumla, A, Doherty, T, Brookes, R
Format: Journal article
Langue:English
Publié: 2004