Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid plaques and neurofibrillary tangles of Alzheimer...

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Bibliografische gegevens
Hoofdauteurs: Wiseman, F, Pulford, L, Barkus, C, Liao, F, Portelius, E, Webb, R, Chávez-Gutiérrez, L, Cleverley, K, Noy, S, Sheppard, O, Collins, T, Powell, C, Sarell, C, Rickman, M, Choong, X, Tosh, J, Siganporia, C, Whittaker, H, Stewart, F, Szaruga, M, London Down Syndrome Consortium, Murphy, M, Blennow, K, De Strooper, B, Zetterberg, H, Bannerman, D, Holtzman, D, Tybulewicz, V, Fisher, E, LonDownS Consortium
Formaat: Journal article
Taal:English
Gepubliceerd in: Oxford University Press 2018

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