Characterising CD8+ T cell transcriptomic and clonal consequences of immune checkpoint blockade for the treatment of cancer

Characterising CD8+ T cell transcriptomic and clonal consequences of immune checkpoint blockade for the treatment of cancer

<p><b>Background:</b> Immune checkpoint blockade (ICB) is arguably the greatest advance in medical oncology this century. Nonetheless, responses are highly variable. Mechanistic insights into this heterogeneity promises to improve patient stratification and identification of thera...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Watson, RA
Awduron Eraill:	Fairfax, B
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2023
Pynciau:	Immunology Immuno-oncology Oncology, Experimental

Eitemau Tebyg

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity
gan: Watson, R, et al.
Cyhoeddwyd: (2021)

Dissecting peripheral CD8+ T cell responses and immune interactions during immune checkpoint blockade for metastatic melanoma
gan: Tong, O
Cyhoeddwyd: (2023)

Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma
gan: Cristina Valero, et al.
Cyhoeddwyd: (2023-10-01)

Mathematical modelling and transcriptional characterisation of intratumoral regulatory T cell sub-populations
gan: Muzhingi, I
Cyhoeddwyd: (2023)

Further Advances in Cancer Immunotherapy: Going Beyond Checkpoint Blockade
gan: Robert W. Wilkinson, et al.
Cyhoeddwyd: (2018-06-01)

New approaches to treating cancer using immune-checkpoint blockade
gan: Fellermeyer, M
Cyhoeddwyd: (2023)

Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
gan: Jun Gong, et al.
Cyhoeddwyd: (2018-10-01)

Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin)
gan: Vassilis Genoud, et al.
Cyhoeddwyd: (2021-11-01)

Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
gan: Joseph S. Dolina, et al.
Cyhoeddwyd: (2023-09-01)

Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell–mediated antitumor immunity
gan: Xiaoxin Ren, et al.
Cyhoeddwyd: (2022-11-01)

IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy
gan: Gürcan Tunalı, et al.
Cyhoeddwyd: (2023-04-01)

Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas
gan: Virginia Laspidea, et al.
Cyhoeddwyd: (2022-04-01)

EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice
gan: Armin Rehm, et al.
Cyhoeddwyd: (2022-06-01)

Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells
gan: Xinyi Jiang, et al.
Cyhoeddwyd: (2023-05-01)

CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity
gan: Madhura Modak, et al.
Cyhoeddwyd: (2022-06-01)

Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer
gan: Kentaro Masuhiro, et al.
Cyhoeddwyd: (2022-05-01)

Tumor-infiltrating exhausted CD8+ T cells dictate reduced survival in premenopausal estrogen receptor–positive breast cancer
gan: Colt A. Egelston, et al.
Cyhoeddwyd: (2022-02-01)

CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy
gan: Miriam Y. Kim, et al.
Cyhoeddwyd: (2021-08-01)

Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models
gan: Xiang Li, et al.
Cyhoeddwyd: (2023-04-01)

Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell– and CXCR3-dependent manner
gan: Michael Brandon Ware, et al.
Cyhoeddwyd: (2023-04-01)

Thromboembolic Events Related to Treatment with Checkpoint Inhibitors: Report of Two Cases
gan: Jessica Tsukamoto, et al.
Cyhoeddwyd: (2018-10-01)

Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer
gan: Elizabeth Comen, et al.
Cyhoeddwyd: (2024-02-01)

Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis
gan: Tiina E. Kähkönen, et al.
Cyhoeddwyd: (2021-06-01)

Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses
gan: Gabrielle Romain, et al.
Cyhoeddwyd: (2022-09-01)

Editorial: Tumor microenvironment complexity and its therapeutic implications
gan: Denner Santos dos Anjos, et al.
Cyhoeddwyd: (2025-01-01)

Circulating biomarkers in the diagnosis and prognosis of immune checkpoint inhibitor-related myocarditis: time for a risk-based approach
gan: Gillian Murtagh, et al.
Cyhoeddwyd: (2024-02-01)

PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors
gan: Rebekka Duhen, et al.
Cyhoeddwyd: (2022-06-01)

Immune regulatory networks in inflammation-driven cancer
gan: Franchini, F
Cyhoeddwyd: (2017)

A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
gan: Alessandro Mega, et al.
Cyhoeddwyd: (2023-12-01)

Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells
gan: Spencer E. Brightman, et al.
Cyhoeddwyd: (2023-01-01)

CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer
gan: Masayo Ukita, et al.
Cyhoeddwyd: (2022-06-01)

A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity
gan: Diana I. Albu, et al.
Cyhoeddwyd: (2024-12-01)

Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC
gan: Eric Tu, et al.
Cyhoeddwyd: (2022-02-01)

MMP2 and TLRs modulate immune responses in the tumor microenvironment
gan: Luciana R. Muniz-Bongers, et al.
Cyhoeddwyd: (2021-06-01)

Tim-3 mediates T cell trogocytosis to limit antitumor immunity
gan: Ornella Pagliano, et al.
Cyhoeddwyd: (2022-05-01)

The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma
gan: Tyler J. Alban, et al.
Cyhoeddwyd: (2023-07-01)

Epigenetic priming enhances antitumor immunity in platinum-resistant ovarian cancer
gan: Siqi Chen, et al.
Cyhoeddwyd: (2022-07-01)

Integrated T cell cytometry metrics for immune-monitoring applications in immunotherapy clinical trials
gan: Dimitrios N. Sidiropoulos, et al.
Cyhoeddwyd: (2022-10-01)

The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response
gan: William Dunker, et al.
Cyhoeddwyd: (2023-06-01)

VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment
gan: Yuqing Zhang, et al.
Cyhoeddwyd: (2021-12-01)