Characterising CD8+ T cell transcriptomic and clonal consequences of immune checkpoint blockade for the treatment of cancer

Characterising CD8+ T cell transcriptomic and clonal consequences of immune checkpoint blockade for the treatment of cancer

<p><b>Background:</b> Immune checkpoint blockade (ICB) is arguably the greatest advance in medical oncology this century. Nonetheless, responses are highly variable. Mechanistic insights into this heterogeneity promises to improve patient stratification and identification of thera...

書誌詳細
第一著者:	Watson, RA
その他の著者:	Fairfax, B
フォーマット:	学位論文
言語:	English
出版事項:	2023
主題:	Immunology Immuno-oncology Oncology, Experimental

類似資料

Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity
著者:: Watson, R, 等
出版事項: (2021)

Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
著者:: Sharmila Nair, 等
出版事項: (2021-01-01)

Dissecting peripheral CD8+ T cell responses and immune interactions during immune checkpoint blockade for metastatic melanoma
著者:: Tong, O
出版事項: (2023)

Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma
著者:: Cristina Valero, 等
出版事項: (2023-10-01)

Mathematical modelling and transcriptional characterisation of intratumoral regulatory T cell sub-populations
著者:: Muzhingi, I
出版事項: (2023)

Further Advances in Cancer Immunotherapy: Going Beyond Checkpoint Blockade
著者:: Robert W. Wilkinson, 等
出版事項: (2018-06-01)

New approaches to treating cancer using immune-checkpoint blockade
著者:: Fellermeyer, M
出版事項: (2023)

FcγRIIB is a T cell checkpoint in antitumor immunity
著者:: Clara R. Farley, 等
出版事項: (2021-02-01)

Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
著者:: Jun Gong, 等
出版事項: (2018-10-01)

Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin)
著者:: Vassilis Genoud, 等
出版事項: (2021-11-01)

Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
著者:: Joseph S. Dolina, 等
出版事項: (2023-09-01)

Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell–mediated antitumor immunity
著者:: Xiaoxin Ren, 等
出版事項: (2022-11-01)

A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity
著者:: Nadine Nelson, 等
出版事項: (2019-08-01)

IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy
著者:: Gürcan Tunalı, 等
出版事項: (2023-04-01)

Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas
著者:: Virginia Laspidea, 等
出版事項: (2022-04-01)

EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice
著者:: Armin Rehm, 等
出版事項: (2022-06-01)

Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells
著者:: Xinyi Jiang, 等
出版事項: (2023-05-01)

CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity
著者:: Madhura Modak, 等
出版事項: (2022-06-01)

Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer
著者:: Kentaro Masuhiro, 等
出版事項: (2022-05-01)

Tumor-infiltrating exhausted CD8+ T cells dictate reduced survival in premenopausal estrogen receptor–positive breast cancer
著者:: Colt A. Egelston, 等
出版事項: (2022-02-01)

CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy
著者:: Miriam Y. Kim, 等
出版事項: (2021-08-01)

Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models
著者:: Xiang Li, 等
出版事項: (2023-04-01)

Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell– and CXCR3-dependent manner
著者:: Michael Brandon Ware, 等
出版事項: (2023-04-01)

Thromboembolic Events Related to Treatment with Checkpoint Inhibitors: Report of Two Cases
著者:: Jessica Tsukamoto, 等
出版事項: (2018-10-01)

Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer
著者:: Elizabeth Comen, 等
出版事項: (2024-02-01)

Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis
著者:: Tiina E. Kähkönen, 等
出版事項: (2021-06-01)

Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses
著者:: Gabrielle Romain, 等
出版事項: (2022-09-01)

Editorial: Tumor microenvironment complexity and its therapeutic implications
著者:: Denner Santos dos Anjos, 等
出版事項: (2025-01-01)

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation
著者:: Kathryn E. Beckermann, 等
出版事項: (2020-08-01)

Circulating biomarkers in the diagnosis and prognosis of immune checkpoint inhibitor-related myocarditis: time for a risk-based approach
著者:: Gillian Murtagh, 等
出版事項: (2024-02-01)

PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors
著者:: Rebekka Duhen, 等
出版事項: (2022-06-01)

Systemic inflammation is a determinant of outcomes of CD40 agonist–based therapy in pancreatic cancer patients
著者:: Max M. Wattenberg, 等
出版事項: (2021-03-01)

Immune regulatory networks in inflammation-driven cancer
著者:: Franchini, F
出版事項: (2017)

Immune determinants of Barrett’s progression to esophageal adenocarcinoma
著者:: Kiran H. Lagisetty, 等
出版事項: (2021-01-01)

Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells
著者:: Spencer E. Brightman, 等
出版事項: (2023-01-01)

CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer
著者:: Masayo Ukita, 等
出版事項: (2022-06-01)

A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
著者:: Alessandro Mega, 等
出版事項: (2023-12-01)

IL-32γ potentiates tumor immunity in melanoma
著者:: Thomas Gruber, 等
出版事項: (2020-09-01)

Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC
著者:: Eric Tu, 等
出版事項: (2022-02-01)

A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity
著者:: Diana I. Albu, 等
出版事項: (2024-12-01)