STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C

STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C

Reaction of a 1:1 mixture of penicillin N and 2,2-bis(trideuteriomethyl) penicillin N with partially purified deacetoxy-cephalosporin C/deacetylcephalosporin C synthetase from Cephalosporium acremonium CO 728 resulted in preferential conversion of the protiated substrate, whereas in similar experime...

全面介绍

书目详细资料
Main Authors: Baldwin, J, Adlington, R, Aplin, R, Crouch, N, Schofield, C, Ting, H
格式: Journal article
语言:English
出版: 1987
实物特征
总结:Reaction of a 1:1 mixture of penicillin N and 2,2-bis(trideuteriomethyl) penicillin N with partially purified deacetoxy-cephalosporin C/deacetylcephalosporin C synthetase from Cephalosporium acremonium CO 728 resulted in preferential conversion of the protiated substrate, whereas in similar experiments with a 1:1 mixture of penicillin N and 3-deuteriopenicillin N both substrates were converted at the same rate; these results accord with a stepwise process for hydrogen removal during the ring expansion in which the methyl hydrogen is first removed.

相似书籍