STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C

STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C

Reaction of a 1:1 mixture of penicillin N and 2,2-bis(trideuteriomethyl) penicillin N with partially purified deacetoxy-cephalosporin C/deacetylcephalosporin C synthetase from Cephalosporium acremonium CO 728 resulted in preferential conversion of the protiated substrate, whereas in similar experime...

Полное описание

Библиографические подробности
Главные авторы:	Baldwin, J, Adlington, R, Aplin, R, Crouch, N, Schofield, C, Ting, H
Формат:	Journal article
Язык:	English
Опубликовано:	1987

Схожие документы

The mechanism of the enzymatic ring expansion of penicillin N to deacetoxycephalosporin C
по: Crouch, N, и др.
Опубликовано: (1988)

THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
по: Baldwin, J, и др.
Опубликовано: (1987)

ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
по: Baldwin, J, и др.
Опубликовано: (1987)

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
по: Dubus, A, и др.
Опубликовано: (2001)

Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.
по: Baldwin, J, и др.
Опубликовано: (1988)

Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.
по: Baldwin, J, и др.
Опубликовано: (1987)

PENICILLIN BIOSYNTHESIS - STEREOCHEMICAL DEPENDENCE ON MODE OF 2ND RING-CLOSURE
по: Baldwin, J, и др.
Опубликовано: (1989)

PENICILLIN BIOSYNTHESIS - DEPENDENCE OF SUBSTRATE STEREOCHEMISTRY ON THE MODE OF 2ND RING-CLOSURE
по: Baldwin, J, и др.
Опубликовано: (1990)

AN EFFECTIVE SUBSTITUTE FOR ALPHA-AMINOADIPIC ACID IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
по: Baldwin, J, и др.
Опубликовано: (1987)

Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase.
по: Baldwin, J, и др.
Опубликовано: (1992)

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.
по: Lloyd, MD, и др.
Опубликовано: (2004)

AN EFFICIENT SUBSTITUTE FOR THE ALPHA-AMINOADIPOYL MOIETY OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
по: Baldwin, J, и др.
Опубликовано: (1987)

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).
по: Lee, H, и др.
Опубликовано: (2001)

Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)
по: Shibata, N, и др.
Опубликовано: (1996)

SIDE-CHAIN SPECIFICITY IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
по: Baldwin, J, и др.
Опубликовано: (1990)

THE FATE OF VALINE-OXYGEN DURING PENICILLIN BIOSYNTHESIS
по: Baldwin, J, и др.
Опубликовано: (1989)

Studies on the active site of deacetoxycephalosporin C synthase.
по: Lloyd, MD, и др.
Опубликовано: (1999)

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase.
по: Lipscomb, S, и др.
Опубликовано: (2002)

THE ENZYMATIC CONVERSION OF EXOMETHYLENE CEPHALOSPORIN-C INTO DEACETYL CEPHALOSPORIN-C AND THE ROLE OF MOLECULAR-OXYGEN IN CEPHALOSPORIN-C BIOSYNTHESIS
по: Baldwin, J, и др.
Опубликовано: (1988)

RING EXPANSION OF PENAMS TO CEPHAMS - A POSSIBLE BIOMIMETIC PROCESS
по: Baldwin, J, и др.
Опубликовано: (1987)

THE RING EXPANSION OF PENAMS TO CEPHAMS - A POSSIBLE BIOMIMETIC PROCESS
по: Baldwin, J, и др.
Опубликовано: (1988)

Active site mutations of recombinant deacetoxycephalosporin C synthase.
по: Lee, H, и др.
Опубликовано: (2002)

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.
по: Lee, H, и др.
Опубликовано: (2001)

CARBOCYCLIC RING EXPANSION REACTIONS VIA RADICAL CHAIN PROCESSES
по: Baldwin, J, и др.
Опубликовано: (1989)

Carbocyclic ring expansion reactions via radical chain processes
по: Baldwin, J, и др.
Опубликовано: (1988)

CARBOCYCLIC RING EXPANSION REACTIONS VIA RADICAL CHAIN PROCESSES
по: Baldwin, J, и др.
Опубликовано: (1988)

CARBOCYCLIC RING EXPANSION REACTIONS VIA RADICAL CHAIN PROCESSES .2.
по: Baldwin, J, и др.
Опубликовано: (1991)

The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus.
по: Lee, H, и др.
Опубликовано: (2000)

The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase.
по: Lee, H, и др.
Опубликовано: (2003)

CEPHALOSPORIN-C BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO A KINETIC ISOTOPE EFFECT
по: Baldwin, J, и др.
Опубликовано: (1987)

CEPHALOSPORIN BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO AN ISOTOPE EFFECT
по: Baldwin, J, и др.
Опубликовано: (1991)

Enzymatic synthesis of penicillins and cephalosporins by penicillin acylase /

CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS
по: Baldwin, J, и др.
Опубликовано: (1995)

PENICILLIN BIOSYNTHESIS - ACTIVE SUBSTRATES DERIVED BY METHOXY SUBSTITUTION IN THE VALINYL RESIDUE OF THE NATURAL SUBSTRATE
по: Baldwin, J, и др.
Опубликовано: (1989)

Synthesis of unnatural substrates as mechanistic probes of the penicillin biosynthetic pathway.
по: Baldwin, J, и др.
Опубликовано: (1999)

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.
по: Tarhonskaya, H, и др.
Опубликовано: (2014)

THE ROLE OF MOLECULAR-OXYGEN IN CEPHALOSPORIN-C BIOSYNTHESIS
по: Baldwin, J, и др.
Опубликовано: (1987)

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
по: Xiaofan Niu, и др.
Опубликовано: (2021-12-01)

Synthesis of cephalosporins and penicillins by enzymatic acylation /
по: Takeshi Takahashi

CEPHALOSPORIN-C BIOSYNTHESIS - STEREOCHEMISTRY OF THE INCORPORATION OF D,L,D-ALPHA-AMINODIPOYL-CYSTEINYL-(3S)-[2-2H,4-C-13]VALINE INTO BETA-LACTAM COMPOUNDS
по: Baldwin, J, и др.
Опубликовано: (1989)