Adjusting the neuroimaging statistical inferences for nonstationarity.
In neuroimaging cluster-based inference has generally been found to be more powerful than voxel-wise inference. However standard cluster-based methods assume stationarity (constant smoothness), while under nonstationarity clusters are larger in smooth regions just by chance, making false positive ri...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1826283247805399040 |
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| author | Salimi-Khorshidi, G Smith, S Nichols, T |
| author_facet | Salimi-Khorshidi, G Smith, S Nichols, T |
| author_sort | Salimi-Khorshidi, G |
| collection | OXFORD |
| description | In neuroimaging cluster-based inference has generally been found to be more powerful than voxel-wise inference. However standard cluster-based methods assume stationarity (constant smoothness), while under nonstationarity clusters are larger in smooth regions just by chance, making false positive risk spatially variant. Hayasaka et al. proposed a Random Field Theory (RFT) based nonstationarity adjustment for cluster inference and validated the method in terms of controlling the overall family-wise false positive rate. The RFT-based methods, however, have never been directly assessed in terms of homogeneity of local false positive risk. In this work we propose a new cluster size adjustment that accounts for local smoothness, based on local empirical cluster size distributions and a two-pass permutation method. We also propose a new approach to measure homogeneity of local false positive risk, and use this method to compare the RFT-based and our new empirical adjustment methods. We apply these techniques to both cluster-based and a related inference, threshold-free cluster enhancement (TFCE). Using simulated and real data we confirm the expected heterogeneity in false positive risk with unadjusted cluster inference but find that RFT-based adjustment does not fully eliminate heterogeneity; we also observe that our proposed empirical adjustment dramatically increases the homogeneity and TFCE inference is generally quite robust to nonstationarity. |
| first_indexed | 2024-03-07T00:56:03Z |
| format | Journal article |
| id | oxford-uuid:881fb213-af18-4785-b160-39d5250dcb6e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:56:03Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:881fb213-af18-4785-b160-39d5250dcb6e2022-03-26T22:14:52ZAdjusting the neuroimaging statistical inferences for nonstationarity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:881fb213-af18-4785-b160-39d5250dcb6eEnglishSymplectic Elements at Oxford2009Salimi-Khorshidi, GSmith, SNichols, TIn neuroimaging cluster-based inference has generally been found to be more powerful than voxel-wise inference. However standard cluster-based methods assume stationarity (constant smoothness), while under nonstationarity clusters are larger in smooth regions just by chance, making false positive risk spatially variant. Hayasaka et al. proposed a Random Field Theory (RFT) based nonstationarity adjustment for cluster inference and validated the method in terms of controlling the overall family-wise false positive rate. The RFT-based methods, however, have never been directly assessed in terms of homogeneity of local false positive risk. In this work we propose a new cluster size adjustment that accounts for local smoothness, based on local empirical cluster size distributions and a two-pass permutation method. We also propose a new approach to measure homogeneity of local false positive risk, and use this method to compare the RFT-based and our new empirical adjustment methods. We apply these techniques to both cluster-based and a related inference, threshold-free cluster enhancement (TFCE). Using simulated and real data we confirm the expected heterogeneity in false positive risk with unadjusted cluster inference but find that RFT-based adjustment does not fully eliminate heterogeneity; we also observe that our proposed empirical adjustment dramatically increases the homogeneity and TFCE inference is generally quite robust to nonstationarity. |
| spellingShingle | Salimi-Khorshidi, G Smith, S Nichols, T Adjusting the neuroimaging statistical inferences for nonstationarity. |
| title | Adjusting the neuroimaging statistical inferences for nonstationarity. |
| title_full | Adjusting the neuroimaging statistical inferences for nonstationarity. |
| title_fullStr | Adjusting the neuroimaging statistical inferences for nonstationarity. |
| title_full_unstemmed | Adjusting the neuroimaging statistical inferences for nonstationarity. |
| title_short | Adjusting the neuroimaging statistical inferences for nonstationarity. |
| title_sort | adjusting the neuroimaging statistical inferences for nonstationarity |
| work_keys_str_mv | AT salimikhorshidig adjustingtheneuroimagingstatisticalinferencesfornonstationarity AT smiths adjustingtheneuroimagingstatisticalinferencesfornonstationarity AT nicholst adjustingtheneuroimagingstatisticalinferencesfornonstationarity |