Studying independent Kcna6 knock-out mice reveals toxicity of exogenous LacZ to central nociceptor terminals and differential effects of Kv1.6 on acute and neuropathic pain sensation

The potassium channel Kv1.6 has recently been implicated as a major modulatory channel subunit expressed in primary nociceptors. Furthermore, its expression at juxtaparanodes (JXP) of myelinated primary afferents is induced following traumatic nerve injury as part of an endogenous mechanism to reduc...

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Hlavní autoři: Peck, LJ, Patel, R, Diaz, P, Wintle, YM, Dickenson, AH, Todd, AJ, Calvo, M, Bennett, DLH
Médium: Journal article
Jazyk:English
Vydáno: Society for Neuroscience 2021