Inhibition of a viral prolyl hydroxylase
The hydroxylation of prolyl-residues in eukaryotes is important in collagen biosynthesis and in hypoxic signalling. The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are drug targets for the treatment of anaemia, while the procollagen prolyl hydroxylases and other 2-oxoglutarate dependen...
| Päätekijät: | , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Elsevier
2019
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| _version_ | 1826283270069813248 |
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| author | Langley, G Abboud, M Lohans, C Schofield, C |
| author_facet | Langley, G Abboud, M Lohans, C Schofield, C |
| author_sort | Langley, G |
| collection | OXFORD |
| description | The hydroxylation of prolyl-residues in eukaryotes is important in collagen biosynthesis and in hypoxic signalling. The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are drug targets for the treatment of anaemia, while the procollagen prolyl hydroxylases and other 2-oxoglutarate dependent oxygenases are potential therapeutic targets for treatment of cancer, fibrotic disease, and infection. We describe assay development and inhibition studies for a procollagen prolyl hydroxylase from Paramecium bursaria chlorella virus 1 (vCPH). The results reveal HIF PHD inhibitors in clinical trials also inhibit vCPH. Implications for the targeting of the human PHDs and microbial prolyl hydroxylases are discussed. |
| first_indexed | 2024-03-07T00:56:23Z |
| format | Journal article |
| id | oxford-uuid:8838de20-f9f2-4954-9a8a-1bcb7d423d27 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:56:23Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:8838de20-f9f2-4954-9a8a-1bcb7d423d272022-03-26T22:15:45ZInhibition of a viral prolyl hydroxylaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8838de20-f9f2-4954-9a8a-1bcb7d423d27EnglishSymplectic Elements at OxfordElsevier2019Langley, GAbboud, MLohans, CSchofield, CThe hydroxylation of prolyl-residues in eukaryotes is important in collagen biosynthesis and in hypoxic signalling. The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are drug targets for the treatment of anaemia, while the procollagen prolyl hydroxylases and other 2-oxoglutarate dependent oxygenases are potential therapeutic targets for treatment of cancer, fibrotic disease, and infection. We describe assay development and inhibition studies for a procollagen prolyl hydroxylase from Paramecium bursaria chlorella virus 1 (vCPH). The results reveal HIF PHD inhibitors in clinical trials also inhibit vCPH. Implications for the targeting of the human PHDs and microbial prolyl hydroxylases are discussed. |
| spellingShingle | Langley, G Abboud, M Lohans, C Schofield, C Inhibition of a viral prolyl hydroxylase |
| title | Inhibition of a viral prolyl hydroxylase |
| title_full | Inhibition of a viral prolyl hydroxylase |
| title_fullStr | Inhibition of a viral prolyl hydroxylase |
| title_full_unstemmed | Inhibition of a viral prolyl hydroxylase |
| title_short | Inhibition of a viral prolyl hydroxylase |
| title_sort | inhibition of a viral prolyl hydroxylase |
| work_keys_str_mv | AT langleyg inhibitionofaviralprolylhydroxylase AT abboudm inhibitionofaviralprolylhydroxylase AT lohansc inhibitionofaviralprolylhydroxylase AT schofieldc inhibitionofaviralprolylhydroxylase |