Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria.
A retrospective study of cerebrospinal fluid (CSF) markers of brain parenchymal damage was conducted in Vietnamese adults with severe malaria. Three markers were analysed by immunoassays: the microtubule-associated protein tau, for degenerated axons; neuron-specific enolase (NSE), for neurons; and S...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1826283273060352000 |
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| author | Medana, I Lindert, R Wurster, U Hien, T Day, N Phu, N Mai, N Chuong, L Chau, T Turner, G Farrar, J White, N |
| author_facet | Medana, I Lindert, R Wurster, U Hien, T Day, N Phu, N Mai, N Chuong, L Chau, T Turner, G Farrar, J White, N |
| author_sort | Medana, I |
| collection | OXFORD |
| description | A retrospective study of cerebrospinal fluid (CSF) markers of brain parenchymal damage was conducted in Vietnamese adults with severe malaria. Three markers were analysed by immunoassays: the microtubule-associated protein tau, for degenerated axons; neuron-specific enolase (NSE), for neurons; and S100B for astrocytes. The mean concentration of tau proteins in the CSF was significantly raised in patients with severe malaria compared with controls (P=0.0003) as reported for other central nervous system diseases. By contrast, the mean concentration of NSE and S100B remained within the normal range. Tau levels were associated with duration of coma (P=0.004) and S100B was associated with convulsions (P=0.006). Concentrations of axonal and astrocyte degeneration markers also were associated with vital organ dysfunction. No association was found between the level of markers of brain parenchymal damage on admission and a fatal outcome. On admission to hospital, patients with severe malaria had biochemical evidence of brain parenchymal damage predominantly affecting axons. |
| first_indexed | 2024-03-07T00:56:26Z |
| format | Journal article |
| id | oxford-uuid:883bcb87-60c8-424b-a1ee-6867e4f142cb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:56:26Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:883bcb87-60c8-424b-a1ee-6867e4f142cb2022-03-26T22:15:52ZCerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:883bcb87-60c8-424b-a1ee-6867e4f142cbEnglishSymplectic Elements at Oxford2005Medana, ILindert, RWurster, UHien, TDay, NPhu, NMai, NChuong, LChau, TTurner, GFarrar, JWhite, NA retrospective study of cerebrospinal fluid (CSF) markers of brain parenchymal damage was conducted in Vietnamese adults with severe malaria. Three markers were analysed by immunoassays: the microtubule-associated protein tau, for degenerated axons; neuron-specific enolase (NSE), for neurons; and S100B for astrocytes. The mean concentration of tau proteins in the CSF was significantly raised in patients with severe malaria compared with controls (P=0.0003) as reported for other central nervous system diseases. By contrast, the mean concentration of NSE and S100B remained within the normal range. Tau levels were associated with duration of coma (P=0.004) and S100B was associated with convulsions (P=0.006). Concentrations of axonal and astrocyte degeneration markers also were associated with vital organ dysfunction. No association was found between the level of markers of brain parenchymal damage on admission and a fatal outcome. On admission to hospital, patients with severe malaria had biochemical evidence of brain parenchymal damage predominantly affecting axons. |
| spellingShingle | Medana, I Lindert, R Wurster, U Hien, T Day, N Phu, N Mai, N Chuong, L Chau, T Turner, G Farrar, J White, N Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria. |
| title | Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria. |
| title_full | Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria. |
| title_fullStr | Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria. |
| title_full_unstemmed | Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria. |
| title_short | Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria. |
| title_sort | cerebrospinal fluid levels of markers of brain parenchymal damage in vietnamese adults with severe malaria |
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