PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.
Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797080222624907264 |
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| author | Murad, A Lewis, S Smith, G Collin, S Chen, L Hamdy, F Neal, D Donovan, J Martin, R |
| author_facet | Murad, A Lewis, S Smith, G Collin, S Chen, L Hamdy, F Neal, D Donovan, J Martin, R |
| author_sort | Murad, A |
| collection | OXFORD |
| description | Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found no evidence that rs20417 alters prostate cancer risk (odds ratio (OR(CC and GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20). A meta-analysis of three studies also found little evidence that rs20417 alters risk (pooled OR(CC and GC v GG)=1.04, 95% CI=0.93-1.17), making it unlikely that rs20417 contributes in any major way to prostate cancer aetiology. |
| first_indexed | 2024-03-07T00:57:03Z |
| format | Journal article |
| id | oxford-uuid:887026d3-834d-4bbc-b18b-a5f3f6eaf8f6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:57:03Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:887026d3-834d-4bbc-b18b-a5f3f6eaf8f62022-03-26T22:17:15ZPTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:887026d3-834d-4bbc-b18b-a5f3f6eaf8f6EnglishSymplectic Elements at Oxford2009Murad, ALewis, SSmith, GCollin, SChen, LHamdy, FNeal, DDonovan, JMartin, RProstaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found no evidence that rs20417 alters prostate cancer risk (odds ratio (OR(CC and GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20). A meta-analysis of three studies also found little evidence that rs20417 alters risk (pooled OR(CC and GC v GG)=1.04, 95% CI=0.93-1.17), making it unlikely that rs20417 contributes in any major way to prostate cancer aetiology. |
| spellingShingle | Murad, A Lewis, S Smith, G Collin, S Chen, L Hamdy, F Neal, D Donovan, J Martin, R PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. |
| title | PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. |
| title_full | PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. |
| title_fullStr | PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. |
| title_full_unstemmed | PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. |
| title_short | PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis. |
| title_sort | ptgs2 899g gt c and prostate cancer risk a population based nested case control study protect and a systematic review with meta analysis |
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