R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. Here, we explore the dynamics of Wnt signaling in the colon. We identify two populations of cells with...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Harnack, C, Berger, H, Antanaviciute, A, Vidal, R, Sauer, S, Simmons, A, Meyer, T, Sigal, M
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: Nature Research 2019