A new responder criterion (relative effect per patient (REPP) >0.2) externally validated in a large total hip replacement multicenter cohort (EUROHIP)
<strong>Objective:</strong> To validate a new method to identify responders (relative effect per patient (REPP) >0.2) using the OMERACT-OARSI criteria as gold standard in a large multicentre sample. <strong>Method:</strong> The REPP ([score before – after treatment]...
| Auteurs principaux: | , , , , , |
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| Format: | Journal article |
| Publié: |
Elsevier
2015
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| Résumé: | <strong>Objective:</strong> To validate a new method to identify responders (relative effect per patient (REPP) >0.2) using the OMERACT-OARSI criteria as gold standard in a large multicentre sample. <strong>Method:</strong> The REPP ([score before – after treatment]/score before treatment) was calculated for 845 patients of a large multicenter European cohort study for THR. The patients with a REPP >0.2 were defined as responders. The responder rate was compared to the gold standard (OMERACT-OARSI criteria) using receiver operator characteristic (ROC) curve analysis for sensitivity, specificity and percentage of appropriately classified patients. <strong>Results:</strong> With the criterion REPP>0.2 85.4% of the patients were classified as responders, applying the OARSI-OMERACT criteria 85.7%. The new method had 98.8% sensitivity, 94.2% specificity and 98.1% of the patients were correctly classified compared to the gold standard. <strong>Conclusion:</strong> The external validation showed a high sensitivity and also specificity of a new criterion to identify a responder compared to the gold standard method. It is simple and has no uncertainties due to a single classification criterion. |
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