The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.

The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.

Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 microM. This effect was not detectable in the complete absence of cytoplasmic Ca2+ and when exocytosis was...

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Bibliographic Details
Main Authors: Barg, S, Renström, E, Berggren, P, Bertorello, A, Bokvist, K, Braun, M, Eliasson, L, Holmes, W, Köhler, M, Rorsman, P, Thévenod, F
Format: Journal article
Language:English
Published: 1999

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