Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax.
In this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance. Clinical trials incorporating the measurement of in vivo drug concentrat...
| 主要な著者: | , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2012
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| _version_ | 1826283399952728064 |
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| author | Price, R Auburn, S Marfurt, J Cheng, Q |
| author_facet | Price, R Auburn, S Marfurt, J Cheng, Q |
| author_sort | Price, R |
| collection | OXFORD |
| description | In this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance. Clinical trials incorporating the measurement of in vivo drug concentrations and parasite clearance times are needed to detect early signs of resistance. Analysis of P. vivax growth dynamics ex vivo have defined the criteria for acceptable assay thresholds for drug susceptibility testing, and their subsequent interpretation. Genotyping and next-generation sequencing studies in P. vivax field isolates are set to transform our understanding of the molecular mechanisms of drug resistance. |
| first_indexed | 2024-03-07T00:58:20Z |
| format | Journal article |
| id | oxford-uuid:88da5b9f-f737-454c-aa8b-b487b55eac8b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:58:20Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:88da5b9f-f737-454c-aa8b-b487b55eac8b2022-03-26T22:20:21ZPhenotypic and genotypic characterisation of drug-resistant Plasmodium vivax.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:88da5b9f-f737-454c-aa8b-b487b55eac8bEnglishSymplectic Elements at Oxford2012Price, RAuburn, SMarfurt, JCheng, QIn this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance. Clinical trials incorporating the measurement of in vivo drug concentrations and parasite clearance times are needed to detect early signs of resistance. Analysis of P. vivax growth dynamics ex vivo have defined the criteria for acceptable assay thresholds for drug susceptibility testing, and their subsequent interpretation. Genotyping and next-generation sequencing studies in P. vivax field isolates are set to transform our understanding of the molecular mechanisms of drug resistance. |
| spellingShingle | Price, R Auburn, S Marfurt, J Cheng, Q Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. |
| title | Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. |
| title_full | Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. |
| title_fullStr | Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. |
| title_full_unstemmed | Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. |
| title_short | Phenotypic and genotypic characterisation of drug-resistant Plasmodium vivax. |
| title_sort | phenotypic and genotypic characterisation of drug resistant plasmodium vivax |
| work_keys_str_mv | AT pricer phenotypicandgenotypiccharacterisationofdrugresistantplasmodiumvivax AT auburns phenotypicandgenotypiccharacterisationofdrugresistantplasmodiumvivax AT marfurtj phenotypicandgenotypiccharacterisationofdrugresistantplasmodiumvivax AT chengq phenotypicandgenotypiccharacterisationofdrugresistantplasmodiumvivax |