PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activit...
Main Authors: | Hégarat, N, Vesely, C, Vinod, P, Ocasio, C, Peter, N, Gannon, J, Oliver, A, Novák, B, Hochegger, H |
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Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2014
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