A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease.

Family-based studies to map susceptibility genes through linkage disequilibrium have been successful in early-onset diseases where parental-proband trios are readily collected, but are believed to be unworkable for late-onset diseases such as coronary artery disease (CAD). PROCARDIS is a European mu...