Crotonases: Nature’s exceedingly convertible catalysts

Crotonases: Nature’s exceedingly convertible catalysts

The crotonases comprise a widely distributed enzyme superfamily that has multiple roles in both primary and secondary metabolism. Many crotonases employ oxyanion holemediated stabilization of intermediates to catalyze the reaction of coenzyme A (CoA) thioester substrates (e.g., malonyl-CoA, a,β- uns...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Lohans, C, Wang, D, Wang, J, Hamed, R, Schofield, C
Fformat:	Journal article
Cyhoeddwyd:	American Chemical Society 2017

Eitemau Tebyg

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Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.
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Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.
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Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.
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Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.
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Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
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Leiomyosarcoma of the Vagina: An Exceedingly Rare Diagnosis
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Research on the Degradation Process of Railway Rails Due to Lifespan Exceeding
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