Blood-based proteomic biomarkers of Alzheimer’s disease pathology
The complexity of Alzheimer’s disease (AD) and its long prodromal phase poses challenges for early diagnosis and yet allows for the possibility of the development of disease modifying treatments for secondary prevention. It is, therefore, of importance to develop biomarkers, in particular, in the pr...
| Príomhchruthaitheoirí: | , , |
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| Formáid: | Journal article |
| Foilsithe / Cruthaithe: |
Frontiers
2015
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| _version_ | 1826283426209071104 |
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| author | Baird, A Westwood, S Lovestone, S |
| author_facet | Baird, A Westwood, S Lovestone, S |
| author_sort | Baird, A |
| collection | OXFORD |
| description | The complexity of Alzheimer’s disease (AD) and its long prodromal phase poses challenges for early diagnosis and yet allows for the possibility of the development of disease modifying treatments for secondary prevention. It is, therefore, of importance to develop biomarkers, in particular, in the preclinical or early phases that reflect the pathological characteristics of the disease and, moreover, could be of utility in triaging subjects for preventative therapeutic clinical trials. Much research has sought biomarkers for diagnostic purposes by comparing affected people to unaffected controls. However, given that AD pathology precedes disease onset, a pathology endophenotype design for biomarker discovery creates the opportunity for detection of much earlier markers of disease. Blood-based biomarkers potentially provide a minimally invasive option for this purpose and research in the field has adopted various “omics” approaches in order to achieve this. This review will, therefore, examine the current literature regarding blood-based proteomic biomarkers of AD and its associated pathology. |
| first_indexed | 2024-03-07T00:58:43Z |
| format | Journal article |
| id | oxford-uuid:88fc6c6a-9863-4df8-b371-c669a471e41c |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:58:43Z |
| publishDate | 2015 |
| publisher | Frontiers |
| record_format | dspace |
| spelling | oxford-uuid:88fc6c6a-9863-4df8-b371-c669a471e41c2022-03-26T22:21:22ZBlood-based proteomic biomarkers of Alzheimer’s disease pathologyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:88fc6c6a-9863-4df8-b371-c669a471e41cSymplectic Elements at OxfordFrontiers2015Baird, AWestwood, SLovestone, SThe complexity of Alzheimer’s disease (AD) and its long prodromal phase poses challenges for early diagnosis and yet allows for the possibility of the development of disease modifying treatments for secondary prevention. It is, therefore, of importance to develop biomarkers, in particular, in the preclinical or early phases that reflect the pathological characteristics of the disease and, moreover, could be of utility in triaging subjects for preventative therapeutic clinical trials. Much research has sought biomarkers for diagnostic purposes by comparing affected people to unaffected controls. However, given that AD pathology precedes disease onset, a pathology endophenotype design for biomarker discovery creates the opportunity for detection of much earlier markers of disease. Blood-based biomarkers potentially provide a minimally invasive option for this purpose and research in the field has adopted various “omics” approaches in order to achieve this. This review will, therefore, examine the current literature regarding blood-based proteomic biomarkers of AD and its associated pathology. |
| spellingShingle | Baird, A Westwood, S Lovestone, S Blood-based proteomic biomarkers of Alzheimer’s disease pathology |
| title | Blood-based proteomic biomarkers of Alzheimer’s disease pathology |
| title_full | Blood-based proteomic biomarkers of Alzheimer’s disease pathology |
| title_fullStr | Blood-based proteomic biomarkers of Alzheimer’s disease pathology |
| title_full_unstemmed | Blood-based proteomic biomarkers of Alzheimer’s disease pathology |
| title_short | Blood-based proteomic biomarkers of Alzheimer’s disease pathology |
| title_sort | blood based proteomic biomarkers of alzheimer s disease pathology |
| work_keys_str_mv | AT bairda bloodbasedproteomicbiomarkersofalzheimersdiseasepathology AT westwoods bloodbasedproteomicbiomarkersofalzheimersdiseasepathology AT lovestones bloodbasedproteomicbiomarkersofalzheimersdiseasepathology |