Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.

Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might pote...

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Hlavní autoři: Hester, J, Schiopu, A, Nadig, SN, Wood, K
Médium: Journal article
Jazyk:English
Vydáno: 2012