Synthesis of the pyrrolidinone core of KSM-2690 B.

[reaction: see text] The first synthesis of the pyrrolidinone core of the polyene beta-lactone antibiotic KSM-2690 B is described. An ammonia-free Birch reductive aldol reaction utilizing acetaldehyde is one of the key steps, together with a ruthenium-catalyzed alkene isomerization reaction.

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Príomhchruthaitheoirí: Donohoe, T, Chiu, J, Thomas, R
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2007
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Synthesis of the pyrrolidinone core of KSM-2690 B de réir Donohoe, T, Chiu, J, Thomas, R

Foilsithe / Cruthaithe 2007
Journal article