Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study.
INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomar...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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BioMed Central
2011
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| _version_ | 1797080419692183552 |
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| author | Williams, J Wilcock, G Seeburger, J Dallob, A Laterza, O Potter, W Smith, A |
| author_facet | Williams, J Wilcock, G Seeburger, J Dallob, A Laterza, O Potter, W Smith, A |
| author_sort | Williams, J |
| collection | OXFORD |
| description | INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations. RESULTS: CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aβ1-40's relationship was biphasic. CONCLUSIONS: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all. |
| first_indexed | 2024-03-07T00:59:46Z |
| format | Journal article |
| id | oxford-uuid:89509b70-2685-4ec4-afb2-9e3a38c9d6b8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:59:46Z |
| publishDate | 2011 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:89509b70-2685-4ec4-afb2-9e3a38c9d6b82022-03-26T22:23:41ZNon-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:89509b70-2685-4ec4-afb2-9e3a38c9d6b8EnglishSymplectic Elements at OxfordBioMed Central2011Williams, JWilcock, GSeeburger, JDallob, ALaterza, OPotter, WSmith, A INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations. RESULTS: CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aβ1-40's relationship was biphasic. CONCLUSIONS: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all. |
| spellingShingle | Williams, J Wilcock, G Seeburger, J Dallob, A Laterza, O Potter, W Smith, A Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. |
| title | Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. |
| title_full | Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. |
| title_fullStr | Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. |
| title_full_unstemmed | Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. |
| title_short | Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study. |
| title_sort | non linear relationships of cerebrospinal fluid biomarker levels with cognitive function an observational study |
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