Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy
Drug delivery using synthetic mesoporous nanomaterials, including porous silicon, has been extensively used to ameliorate the constraints currently experienced with conventional chemotherapy. Owing to the amazing potential, the silica based nanomaterials have been used widely. Nevertheless, syntheti...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2018
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| _version_ | 1797080420295114752 |
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| author | Sasirekha, R Sheena, T Sathiya Deepika, M Santhanam, P Townley, H Jeganathan, K Dinesh Kumar, S Premkumar, K |
| author_facet | Sasirekha, R Sheena, T Sathiya Deepika, M Santhanam, P Townley, H Jeganathan, K Dinesh Kumar, S Premkumar, K |
| author_sort | Sasirekha, R |
| collection | OXFORD |
| description | Drug delivery using synthetic mesoporous nanomaterials, including porous silicon, has been extensively used to ameliorate the constraints currently experienced with conventional chemotherapy. Owing to the amazing potential, the silica based nanomaterials have been used widely. Nevertheless, synthetic nanomaterial involves high cost, lack of scalability, and the use of toxic substances limits its utilization. These issues can be overcome by the use of nature generated nanoscale materials, such as diatoms would serve as a boon for pharmaceutical industries. In this study we investigate the use of a mesoporous, biodegradable nanomaterial obtained from the natural silica found in the diatom species Amphora subtropica (AMPS) for drug delivery applications. AMPS cultures cleaned and chemically treated to obtain Amphora frustules (exoskeleton) (AF), followed by surface functionalization with chitosan (Chi). Results of our experiments demonstrate high drug loading, strong luminescence, biodegradable and biocompatible nature of the doxorubicin tethered diatom. Further, toxicity studies employing immortalized lung cancer cell line (A549) indicates sustained drug delivery and less toxic compared to the free doxorubicin (DOX), suggesting AF could be an excellent substitute for synthetic nanomaterials used in drug delivery applications. |
| first_indexed | 2024-03-07T00:59:46Z |
| format | Journal article |
| id | oxford-uuid:8950ef16-b294-4c8a-9af0-4d8823cd4d6c |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:59:46Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:8950ef16-b294-4c8a-9af0-4d8823cd4d6c2022-03-26T22:23:41ZSurface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8950ef16-b294-4c8a-9af0-4d8823cd4d6cSymplectic Elements at OxfordElsevier2018Sasirekha, RSheena, TSathiya Deepika, MSanthanam, PTownley, HJeganathan, KDinesh Kumar, SPremkumar, KDrug delivery using synthetic mesoporous nanomaterials, including porous silicon, has been extensively used to ameliorate the constraints currently experienced with conventional chemotherapy. Owing to the amazing potential, the silica based nanomaterials have been used widely. Nevertheless, synthetic nanomaterial involves high cost, lack of scalability, and the use of toxic substances limits its utilization. These issues can be overcome by the use of nature generated nanoscale materials, such as diatoms would serve as a boon for pharmaceutical industries. In this study we investigate the use of a mesoporous, biodegradable nanomaterial obtained from the natural silica found in the diatom species Amphora subtropica (AMPS) for drug delivery applications. AMPS cultures cleaned and chemically treated to obtain Amphora frustules (exoskeleton) (AF), followed by surface functionalization with chitosan (Chi). Results of our experiments demonstrate high drug loading, strong luminescence, biodegradable and biocompatible nature of the doxorubicin tethered diatom. Further, toxicity studies employing immortalized lung cancer cell line (A549) indicates sustained drug delivery and less toxic compared to the free doxorubicin (DOX), suggesting AF could be an excellent substitute for synthetic nanomaterials used in drug delivery applications. |
| spellingShingle | Sasirekha, R Sheena, T Sathiya Deepika, M Santhanam, P Townley, H Jeganathan, K Dinesh Kumar, S Premkumar, K Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
| title | Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
| title_full | Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
| title_fullStr | Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
| title_full_unstemmed | Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
| title_short | Surface engineered Amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
| title_sort | surface engineered amphora subtropica frustules using chitosan as a drug delivery platform for anticancer therapy |
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