Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

<p><strong>Background:</strong> In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia s...

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מידע ביבליוגרפי
Main Authors:	Lippl, K, Boleininger, A, McDonough, M, Abboud, M, Tarhonskaya, H, Chowdhury, R, Loenarz, C, Schofield, C
פורמט:	Journal article
יצא לאור:	Dove Medical Press 2018

פריטים דומים

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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
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Substrate selectivity of prolyl hydroxylases
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2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
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Inhibition of a viral prolyl hydroxylase
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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
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Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
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2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
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Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
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Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
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Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
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Bioeffects of Prunus spinosa L. fruit ethanol extract on reproduction and phenotypic plasticity of Trichoplax adhaerens Schulze, 1883 (Placozoa)
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Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution
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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
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Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
מאת: Yeh, TL, et al.
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A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
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יצא לאור: (2020)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
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יצא לאור: (2016)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
מאת: Figg, WD, et al.
יצא לאור: (2023)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
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Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
מאת: Tarhonskaya, H, et al.
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
מאת: Chowdhury, R, et al.
יצא לאור: (2016)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
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Structural and mechanistic studies on prolyl hydroxylases
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Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
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יצא לאור: (2013)