Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF, and epigenetic modifications...

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Main Authors: Lannagan, T, Lee, Y, Wang, T, Roper, J, Bettington, M, Fennell, L, Vrbanac, L, Jonavicius, L, Somashekar, R, Gieniec, K, Yang, M, Ng, J, Suzuki, N, Ichinose, M, Wright, J, Kobayashi, H, Putoczki, T, Hayakawa, Y, Leedham, S, Abud, H, Yilmaz, Ö, Marker, J, Klebe, S, Wirapati, P, Mukherjee, S, Tejpar, S, Leggett, B, Whitehall, V, Worthley, D, Woods, S
Format: Journal article
Language:English
Published: BMJ Publishing Group 2018

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