The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

Detaylı Bibliyografya
Asıl Yazarlar:	Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Russell, R, Kavanagh, K
Materyal Türü:	Conference item
Baskı/Yayın Bilgisi:	2008

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
Yazar:: Kwassi, A, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Yazar:: Tsoumpra, MK, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Yazar:: Tsoumpra, M, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
Yazar:: Tsoumpra, M, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
Yazar:: Dunford, J, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
Yazar:: Hogan, J, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
Yazar:: Evdokimov, A, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
Yazar:: Kavanagh, K, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
Yazar:: L. O. Metelytsia, ve diğerleri
Baskı/Yayın Bilgisi: (2019-05-01)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Yazar:: Räikkönen, J, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
Yazar:: Räikkönen, J, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
Yazar:: Xia, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
Yazar:: Lundy, M, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
Yazar:: Xia, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
Yazar:: Kavanagh, K, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Yazar:: Kavanagh, K, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
Yazar:: Xia, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.
Yazar:: Ebetino, F, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells
Yazar:: Wei Xu, ve diğerleri
Baskı/Yayın Bilgisi: (2024-09-01)

Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
Yazar:: Saman Salari, ve diğerleri
Baskı/Yayın Bilgisi: (2024-08-01)

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
Yazar:: Yu-Jun Zhao, ve diğerleri
Baskı/Yayın Bilgisi: (2015-01-01)

Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors.
Yazar:: Jennifer Alcaíno, ve diğerleri
Baskı/Yayın Bilgisi: (2014-01-01)

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
Yazar:: Artz, J, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

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