The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

Библиографические подробности
Главные авторы:	Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Russell, R, Kavanagh, K
Формат:	Conference item
Опубликовано:	2008

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
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Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
по: Dunford, J, и др.
Опубликовано: (2008)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
по: Dunford, J, и др.
Опубликовано: (2008)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
по: Tsoumpra, MK, и др.
Опубликовано: (2015)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
по: Tsoumpra, M, и др.
Опубликовано: (2015)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
по: Dunford, J, и др.
Опубликовано: (2008)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
по: Dunford, J, и др.
Опубликовано: (2006)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2007)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
по: Dunford, J, и др.
Опубликовано: (2008)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
по: Dunford, J, и др.
Опубликовано: (2007)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
по: Tsoumpra, M, и др.
Опубликовано: (2010)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
по: Dunford, J, и др.
Опубликовано: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2006)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2005)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
по: Hogan, J, и др.
Опубликовано: (2007)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
по: Evdokimov, A, и др.
Опубликовано: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2006)

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2008)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
по: Kavanagh, K, и др.
Опубликовано: (2005)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2002)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
по: Ebetino, F, и др.
Опубликовано: (2007)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
по: Ebetino, F, и др.
Опубликовано: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
по: Ebetino, F, и др.
Опубликовано: (2002)

New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
по: L. O. Metelytsia, и др.
Опубликовано: (2019-05-01)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
по: Räikkönen, J, и др.
Опубликовано: (2011)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
по: Räikkönen, J, и др.
Опубликовано: (2011)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
по: Xia, Z, и др.
Опубликовано: (2007)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
по: Ebetino, F, и др.
Опубликовано: (2006)

Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
по: Lundy, M, и др.
Опубликовано: (2007)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
по: Xia, Z, и др.
Опубликовано: (2006)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
по: Jaeok Park, и др.
Опубликовано: (2021-01-01)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
по: Kavanagh, K, и др.
Опубликовано: (2006)

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
по: Kavanagh, K, и др.
Опубликовано: (2006)

Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
по: Xia, Z, и др.
Опубликовано: (2007)

The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.
по: Ebetino, F, и др.
Опубликовано: (2013)

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells
по: Wei Xu, и др.
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Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
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Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
по: Jaeok Park, и др.
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The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

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