The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

Bibliografiska uppgifter
Huvudupphovsmän:	Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Russell, R, Kavanagh, K
Materialtyp:	Conference item
Publicerad:	2008

Liknande verk

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
av: Kwassi, A, et al.
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Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
av: Dunford, J, et al.
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The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
av: Dunford, J, et al.
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The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
av: Tsoumpra, MK, et al.
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The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
av: Tsoumpra, M, et al.
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Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
av: Dunford, J, et al.
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Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
av: Dunford, J, et al.
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The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
av: Ebetino, F, et al.
Publicerad: (2007)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
av: Dunford, J, et al.
Publicerad: (2008)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
av: Dunford, J, et al.
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Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
av: Dunford, J, et al.
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Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
av: Tsoumpra, M, et al.
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Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
av: Dunford, J, et al.
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Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
av: Ebetino, F, et al.
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Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
av: Ebetino, F, et al.
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MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
av: Hogan, J, et al.
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Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
av: Evdokimov, A, et al.
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Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
av: Ebetino, F, et al.
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A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
av: Ebetino, F, et al.
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Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
av: Kavanagh, K, et al.
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Modeling of bisphosphonate binding to farnesyl diphosphate synthase
av: Ebetino, F, et al.
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Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
av: Ebetino, F, et al.
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Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
av: Ebetino, F, et al.
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Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
av: Ebetino, F, et al.
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New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
av: L. O. Metelytsia, et al.
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Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
av: Räikkönen, J, et al.
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Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
av: Räikkönen, J, et al.
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Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
av: Xia, Z, et al.
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Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
av: Ebetino, F, et al.
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Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
av: Lundy, M, et al.
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Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
av: Xia, Z, et al.
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Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
av: Jaeok Park, et al.
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Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
av: Kavanagh, K, et al.
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The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
av: Kavanagh, K, et al.
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Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
av: Xia, Z, et al.
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The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.
av: Ebetino, F, et al.
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Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells
av: Wei Xu, et al.
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Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
av: Saman Salari, et al.
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Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
av: Yu-Jun Zhao, et al.
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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
av: Jaeok Park, et al.
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