Expression of HLA system antigens on placenta.
The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally a...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1976
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| _version_ | 1826283593636249600 |
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| author | Goodfellow, P Barnstable, C Bodmer, W Snary, D Crumpton, M |
| author_facet | Goodfellow, P Barnstable, C Bodmer, W Snary, D Crumpton, M |
| author_sort | Goodfellow, P |
| collection | OXFORD |
| description | The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inherited A and B antigen activities and beta2-microglobulin are expressed to similar extents but at much lower levels than in spleen lymphocytes (less than 5%). The possibility that the amounts detected were caused by contamination with blood or maternal tissue was ruled out. The low levels of A and B antigens may account for the lack of a cellular immune response to the other polymorphic cell surface antigens of the trophoblast. No evidence was obtained for the expression of a significant level of Ia antigens. |
| first_indexed | 2024-03-07T01:01:12Z |
| format | Journal article |
| id | oxford-uuid:89cc2efd-d778-4f82-b3f5-9d7483cea5e7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:01:12Z |
| publishDate | 1976 |
| record_format | dspace |
| spelling | oxford-uuid:89cc2efd-d778-4f82-b3f5-9d7483cea5e72022-03-26T22:26:59ZExpression of HLA system antigens on placenta.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:89cc2efd-d778-4f82-b3f5-9d7483cea5e7EnglishSymplectic Elements at Oxford1976Goodfellow, PBarnstable, CBodmer, WSnary, DCrumpton, MThe levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inherited A and B antigen activities and beta2-microglobulin are expressed to similar extents but at much lower levels than in spleen lymphocytes (less than 5%). The possibility that the amounts detected were caused by contamination with blood or maternal tissue was ruled out. The low levels of A and B antigens may account for the lack of a cellular immune response to the other polymorphic cell surface antigens of the trophoblast. No evidence was obtained for the expression of a significant level of Ia antigens. |
| spellingShingle | Goodfellow, P Barnstable, C Bodmer, W Snary, D Crumpton, M Expression of HLA system antigens on placenta. |
| title | Expression of HLA system antigens on placenta. |
| title_full | Expression of HLA system antigens on placenta. |
| title_fullStr | Expression of HLA system antigens on placenta. |
| title_full_unstemmed | Expression of HLA system antigens on placenta. |
| title_short | Expression of HLA system antigens on placenta. |
| title_sort | expression of hla system antigens on placenta |
| work_keys_str_mv | AT goodfellowp expressionofhlasystemantigensonplacenta AT barnstablec expressionofhlasystemantigensonplacenta AT bodmerw expressionofhlasystemantigensonplacenta AT snaryd expressionofhlasystemantigensonplacenta AT crumptonm expressionofhlasystemantigensonplacenta |