Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

Mutations in the MEN1 gene are associated with the multiple endocrine neoplasia syndrome type 1 (MEN1), which is characterized by parathyroid hyperplasia and tumors of the pituitary and pancreatic islets. The mechanism by which MEN1 acts as a tumor suppressor is unclear. We have recently shown that...

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Bibliographic Details
Main Authors: Milne, T, Hughes, C, Lloyd, R, Yang, Z, Rozenblatt-Rosen, O, Dou, Y, Schnepp, R, Krankel, C, Livolsi, V, Gibbs, D, Hua, X, Roeder, R, Meyerson, M, Hess, J
Format: Journal article
Language:English
Published: 2005

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