Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases
The cytochrome P450 superfamily of heme monooxygenases catalyzes important chemical reactions across nature. The changes in the optical spectra of these enzymes, induced by the addition of substrates or inhibitors, are critical for assessing how these molecules bind to the P450, enhancing or inhibit...
Main Authors: | Podgorski, MN, Harbort, JS, Coleman, T, Stok, JE, Yorke, JA, Wong. L-L, Bruning, JB, Bernhardt, PV, De Voss, JJ, Harmer, JR, Bell, SG |
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Formato: | Journal article |
Idioma: | English |
Publicado em: |
American Chemical Society
2020
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