Intraosseous pressure during loading and with vascular occlusion
<p>We studied subchondral intraosseous pressure (IOP) in an animal model during loading and with vascular occlusion. We explored bone compartmentalisation by saline injection.</p> <br/> <p>Needles were placed in the femoral condyle and upper tibia of 5 anaesthetised rabbits...
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| 格式: | Journal article |
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British Editorial Society of Bone and Joint Surgery
2018
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| _version_ | 1826283613083140096 |
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| author | Beverly, M Mellon, S Kennedy, J Murray, D |
| author_facet | Beverly, M Mellon, S Kennedy, J Murray, D |
| author_sort | Beverly, M |
| collection | OXFORD |
| description | <p>We studied subchondral intraosseous pressure (IOP) in an animal model during loading and with vascular occlusion. We explored bone compartmentalisation by saline injection.</p> <br/> <p>Needles were placed in the femoral condyle and upper tibia of 5 anaesthetised rabbits and connected to pressure recorders. The limb was loaded with and without proximal vascular occlusion. An additional subject had simultaneous triple recordings at the femoral head, femoral condyle and proximal tibia. In a further subject saline injections at three sites were carried out alternately.</p> <br/> <p>Loading alone caused a rise in subchondral IOP from 11.7mmHg (SD 7.1mmHg) to 17.9mmHg (SD 8.1mmHg) p<0.0002. During arterial occlusion IOP fell to 5.3mmHg (SD 4.1mmHg) then with loading there was a small rise to 7.6mmHg (SD 4.5mmHg) p<0.002. During venous occlusion IOP rose to 20.2mmHg (SD 5.8mmHg) and with loading there was a further rise to 26.3mmHg (SD 6.3mmHg) p<0.003. The effects were present at three different sites along the limb simultaneously. Saline injections showed pressure transmitted throughout the length of the femur but not across the knee joint.</p> <br/> <p>This is the first study to report changes in IOP in vivo during loading and with combinations of vascular occlusion and loading. IOP is not a constant but is reduced during proximal arterial occlusion and increased with proximal venous occlusion. Whatever the perfusion state, in vivo load is transferred partly by hydraulic pressure. We suggest that joints act as hydraulic pressure barriers. An understanding of subchondral physiology may be important in understanding osteoarthritis and other bone diseases.</p> |
| first_indexed | 2024-03-07T01:01:30Z |
| format | Journal article |
| id | oxford-uuid:89e46b46-1ca5-4782-9f5c-a0d55c05e574 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:01:30Z |
| publishDate | 2018 |
| publisher | British Editorial Society of Bone and Joint Surgery |
| record_format | dspace |
| spelling | oxford-uuid:89e46b46-1ca5-4782-9f5c-a0d55c05e5742022-03-26T22:27:38ZIntraosseous pressure during loading and with vascular occlusionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:89e46b46-1ca5-4782-9f5c-a0d55c05e574Symplectic Elements at OxfordBritish Editorial Society of Bone and Joint Surgery2018Beverly, MMellon, SKennedy, JMurray, D <p>We studied subchondral intraosseous pressure (IOP) in an animal model during loading and with vascular occlusion. We explored bone compartmentalisation by saline injection.</p> <br/> <p>Needles were placed in the femoral condyle and upper tibia of 5 anaesthetised rabbits and connected to pressure recorders. The limb was loaded with and without proximal vascular occlusion. An additional subject had simultaneous triple recordings at the femoral head, femoral condyle and proximal tibia. In a further subject saline injections at three sites were carried out alternately.</p> <br/> <p>Loading alone caused a rise in subchondral IOP from 11.7mmHg (SD 7.1mmHg) to 17.9mmHg (SD 8.1mmHg) p<0.0002. During arterial occlusion IOP fell to 5.3mmHg (SD 4.1mmHg) then with loading there was a small rise to 7.6mmHg (SD 4.5mmHg) p<0.002. During venous occlusion IOP rose to 20.2mmHg (SD 5.8mmHg) and with loading there was a further rise to 26.3mmHg (SD 6.3mmHg) p<0.003. The effects were present at three different sites along the limb simultaneously. Saline injections showed pressure transmitted throughout the length of the femur but not across the knee joint.</p> <br/> <p>This is the first study to report changes in IOP in vivo during loading and with combinations of vascular occlusion and loading. IOP is not a constant but is reduced during proximal arterial occlusion and increased with proximal venous occlusion. Whatever the perfusion state, in vivo load is transferred partly by hydraulic pressure. We suggest that joints act as hydraulic pressure barriers. An understanding of subchondral physiology may be important in understanding osteoarthritis and other bone diseases.</p> |
| spellingShingle | Beverly, M Mellon, S Kennedy, J Murray, D Intraosseous pressure during loading and with vascular occlusion |
| title | Intraosseous pressure during loading and with vascular occlusion |
| title_full | Intraosseous pressure during loading and with vascular occlusion |
| title_fullStr | Intraosseous pressure during loading and with vascular occlusion |
| title_full_unstemmed | Intraosseous pressure during loading and with vascular occlusion |
| title_short | Intraosseous pressure during loading and with vascular occlusion |
| title_sort | intraosseous pressure during loading and with vascular occlusion |
| work_keys_str_mv | AT beverlym intraosseouspressureduringloadingandwithvascularocclusion AT mellons intraosseouspressureduringloadingandwithvascularocclusion AT kennedyj intraosseouspressureduringloadingandwithvascularocclusion AT murrayd intraosseouspressureduringloadingandwithvascularocclusion |