Competition shapes the landscape of X-chromosome-linked genetic diversity
X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals. Combined with sequence variation between human X chromosomes, XCI gives rise to intra-individual clonal diversity, whereby two sets of clones express mutually exclusive sequence variants present on one or the other...
Main Authors: | Buenaventura, T, Bagci, H, Patrascan, I, Graham, JJ, Hipwell, KD, Oldenkamp, R, King, JWD, Urtasun, J, Young, G, Mouzo, D, Gomez-Cabrero, D, Rowland, BD, Panne, D, Fisher, AG, Merkenschlager, M |
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Format: | Journal article |
Language: | English |
Published: |
Nature Research
2024
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