Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules
The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction co...
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| Format: | Journal article |
| Language: | English |
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Royal Society of Chemistry
2019
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| _version_ | 1797080559577464832 |
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| author | Lee, V |
| author_facet | Lee, V |
| author_sort | Lee, V |
| collection | OXFORD |
| description | The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(i) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018. |
| first_indexed | 2024-03-07T01:01:53Z |
| format | Journal article |
| id | oxford-uuid:8a019372-9a60-4a91-9a5a-2bedbeb47ac0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:01:53Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:8a019372-9a60-4a91-9a5a-2bedbeb47ac02022-03-26T22:28:30ZApplication of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive moleculesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8a019372-9a60-4a91-9a5a-2bedbeb47ac0EnglishSymplectic Elements at OxfordRoyal Society of Chemistry2019Lee, VThe Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(i) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018. |
| spellingShingle | Lee, V Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules |
| title | Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules |
| title_full | Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules |
| title_fullStr | Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules |
| title_full_unstemmed | Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules |
| title_short | Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules |
| title_sort | application of copper i salt and fluoride promoted stille coupling reactions in the synthesis of bioactive molecules |
| work_keys_str_mv | AT leev applicationofcopperisaltandfluoridepromotedstillecouplingreactionsinthesynthesisofbioactivemolecules |