Length-independent structural similarities enrich the antibody CDR canonical class model

Complementarity-determining regions (CDRs) are antibody loops that make up the antigen binding site. Here, we show that all CDR types have structurally similar loops of different lengths. Based on these findings, we created length-independent canonical classes for the non-H3 CDRs. Our length variabl...

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Hlavní autoři: Nowak, J, Baker, T, Georges, G, Kelm, S, Klostermann, S, Shi, J, Sridharan, S, Deane, C
Médium: Journal article
Jazyk:English
Vydáno: Taylor and Francis 2016