Defining the structural basis of human plasminogen binding by streptococcal surface enolase.
The flesh-eating bacterium group A Streptococcus (GAS) binds and activates human plasminogen, promoting invasive disease. Streptococcal surface enolase (SEN), a glycolytic pathway enzyme, is an identified plasminogen receptor of GAS. Here we used mass spectrometry (MS) to confirm that GAS SEN is oct...
Main Authors: | Cork, A, Jergic, S, Hammerschmidt, S, Kobe, B, Pancholi, V, Benesch, J, Robinson, C, Dixon, N, Aquilina, J, Walker, M |
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Format: | Journal article |
Language: | English |
Published: |
2009
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