Human and Mouse Gastrointestinal Tumor Distribution is Selected According to a Basal Wnt Signalling Gradient

Human and Mouse Gastrointestinal Tumor Distribution is Selected According to a Basal Wnt Signalling Gradient

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Príomhchruthaitheoirí:	Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffery, R, Rodriguez-Justo, M, Clark, S, East, J, Travis, S, Tomlinson, I, Leedham, S
Formáid:	Conference item
Foilsithe / Cruthaithe:	2011

Míreanna comhchosúla

HUMAN AND MOUSE GASTROINTESTINAL TUMOUR DISTRIBUTION IS SELECTED ACCORDING TO A BASAL INTESTINAL WNT SIGNALLING GRADIENT
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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.
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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts
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The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.
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Not all Wnt activation is equal: ligand-dependent versus ligand-independent wnt activation in colorectal cancer
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Causality and chance in the development of cancer
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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
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WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling
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Wnt disruption in colorectal polyps - the traditional serrated adenoma enters the fray
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Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
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Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
de réir: Jaeger, E, et al.
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Wnt Signaling in the Gastrointestinal Tract in Health and Disease
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Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA In Situ Hybridisation
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Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium
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Colonoscopy, tumors
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Colonoscopy, tumors
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Multimodal gradients of basal forebrain connectivity across the neocortex
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Epigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components.
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Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
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Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5
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Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.
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Colorectal cancer and genetic alterations in the Wnt pathway.
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Diagnosis of sessile serrated polyps/adenomas: What does this mean for the pathologist, gastroenterologist and patient
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Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal
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Modelling Wnt/β-catenin target gene expression in APC and Wnt gradients under wild type and mutant conditions
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A gradient of Wnt activity positions the neurosensory domains of the inner ear
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Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae.
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The continuum model of selection in human tumors: general paradigm or niche product?
de réir: Leedham, S, et al.
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Diagnosis of sessile serrated polyps/adenomas: what does this mean for the pathologist, gastroenterologist and patient?
de réir: Leedham, S, et al.
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Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification
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Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans
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Evaluation of surgical margins according to the histological type of basal cell carcinoma
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The utility of mouse models in post-GWAS research
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Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.
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Patched Knockout Mouse Models of Basal Cell Carcinoma
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Complete morphologies of basal forebrain cholinergic neurons in the mouse
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Canonical Wnt signaling is not required for Tgfb3 expression in the basal medial edge epithelium during palatogenesis
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Disturbances and environmental gradients influence the dynamics of individuals and basal area in the Cerrado complex
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Cancer. The utility of mouse models in post-GWAS research.
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Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma.
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