Five computational developability guidelines for therapeutic antibody profiling

Five computational developability guidelines for therapeutic antibody profiling

Therapeutic mAbs must not only bind to their target but must also be free from “developability issues” such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski’s rule of five to guide the selection of molecules with appropriate biophysical prop...

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Dades bibliogràfiques
Autors principals:	Raybould, MIJ, Marks, C, Krawczyk, K, Taddese, B, Nowak, J, Lewis, AP, Bujotzek, A, Shi, J, Deane, C
Format:	Journal article
Publicat:	National Academy of Sciences 2019

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