Five computational developability guidelines for therapeutic antibody profiling

Five computational developability guidelines for therapeutic antibody profiling

Therapeutic mAbs must not only bind to their target but must also be free from “developability issues” such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski’s rule of five to guide the selection of molecules with appropriate biophysical prop...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Raybould, MIJ, Marks, C, Krawczyk, K, Taddese, B, Nowak, J, Lewis, AP, Bujotzek, A, Shi, J, Deane, C
Fformat:	Journal article
Cyhoeddwyd:	National Academy of Sciences 2019

Eitemau Tebyg

Thera-SAbDab: the Therapeutic Structural Antibody Database
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2019)

Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies
gan: Robinson, SA, et al.
Cyhoeddwyd: (2021)

Public Baseline and shared response structures support the theory of antibody repertoire functional commonality
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2021)

Computationally profiling peptide: MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2023)

Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profiling
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2024)

CoV-AbDab: the coronavirus antibody database
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2020)

Prospects for the computational humanization of antibodies and nanobodies
gan: Gordon, GL, et al.
Cyhoeddwyd: (2024)

Structure-aware tools for the development of therapeutic antibodies from natural immunoglobulins
gan: Raybould, MIJ
Cyhoeddwyd: (2020)

Looking for therapeutic antibodies in next-generation sequencing repositories
gan: Krawczyk, K, et al.
Cyhoeddwyd: (2019)

Looking for therapeutic antibodies in next-generation sequencing repositories
gan: Konrad Krawczyk, et al.
Cyhoeddwyd: (2019-10-01)

Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope
gan: Wong, WK, et al.
Cyhoeddwyd: (2021)

Current strategies for detecting functional convergence across B-cell receptor repertoires
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2021)

Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies.
gan: Sarah A Robinson, et al.
Cyhoeddwyd: (2021-12-01)

Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profiling
gan: Matthew I. J. Raybould, et al.
Cyhoeddwyd: (2024-01-01)

The patent and literature antibody database (PLAbDab): an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures
gan: Abanades, B, et al.
Cyhoeddwyd: (2023)

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies
gan: Matthew I. J. Raybould, et al.
Cyhoeddwyd: (2023-01-01)

Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and mice
gan: Kovaltsuk, A, et al.
Cyhoeddwyd: (2020)

Prospects for the computational humanization of antibodies and nanobodies
gan: Gemma L. Gordon, et al.
Cyhoeddwyd: (2024-05-01)

Improved computational epitope profiling using structural models identifies a broader diversity of antibodies that bind to the same epitope
gan: Fabian C. Spoendlin, et al.
Cyhoeddwyd: (2023-09-01)

Antibody–antigen complex modelling in the era of immunoglobulin repertoire sequencing
gan: Raybould, M, et al.
Cyhoeddwyd: (2019)

Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope
gan: Wing Ki Wong, et al.
Cyhoeddwyd: (2021-01-01)

Public Baseline and shared response structures support the theory of antibody repertoire functional commonality.
gan: Matthew I J Raybould, et al.
Cyhoeddwyd: (2021-03-01)

SAbPred: a structure-based antibody prediction server
gan: Deane, C, et al.
Cyhoeddwyd: (2016)

Antibody i-Patch prediction of the antibody binding site improves rigid local antibody-antigen docking.
gan: Krawczyk, K, et al.
Cyhoeddwyd: (2013)

ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation
gan: Abanades, B, et al.
Cyhoeddwyd: (2022)

Antibody H3 structure prediction
gan: Marks, C, et al.
Cyhoeddwyd: (2017)

T-cell receptor structures and predictive models reveal comparable alpha and beta chain structural diversity despite differing genetic complexity
gan: Quast, NP, et al.
Cyhoeddwyd: (2025)

SCALOP: sequence-based antibody canonical loop structure annotation
gan: Wong, W, et al.
Cyhoeddwyd: (2018)

DLAB: deep learning methods for structure-based virtual screening of antibodies
gan: Schneider, C, et al.
Cyhoeddwyd: (2021)

Observed antibody space: a resource for data mining next generation sequencing of antibody repertoires
gan: Kovaltsuk, A, et al.
Cyhoeddwyd: (2018)

Computational antibody design
gan: Krawczyk, K
Cyhoeddwyd: (2013)

LAP: Liability Antibody Profiler by sequence & structural mapping of natural and therapeutic antibodies.
gan: Tadeusz Satława, et al.
Cyhoeddwyd: (2024-03-01)

Improving B-cell epitope prediction and its application to global antibody-antigen docking.
gan: Krawczyk, K, et al.
Cyhoeddwyd: (2014)

Filtering next-generation sequencing of the Ig gene repertoire data using antibody structural information
gan: Kovaltsuk, A, et al.
Cyhoeddwyd: (2018)

Filtering next-generation sequencing of the Ig gene repertoire data using antibody structural information
gan: Kovaltsuk, A, et al.
Cyhoeddwyd: (2018)

SAbDab in the age of biotherapeutics: updates including SAbDab-nano, the nanobody structure tracker
gan: Schneider, C, et al.
Cyhoeddwyd: (2021)

The observed T cell receptor space database enables paired-chain repertoire mining, coherence analysis and language modelling
gan: Raybould, MIJ, et al.
Cyhoeddwyd: (2024)

TCRBuilder: multi-state T-cell receptor structure prediction
gan: Wong, WK, et al.
Cyhoeddwyd: (2020)

SAbDab: the structural antibody database
gan: Dunbar, J, et al.
Cyhoeddwyd: (2014)

SAbDab: the structural antibody database.
gan: Dunbar, J, et al.
Cyhoeddwyd: (2014)