Five computational developability guidelines for therapeutic antibody profiling
Therapeutic mAbs must not only bind to their target but must also be free from “developability issues” such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski’s rule of five to guide the selection of molecules with appropriate biophysical prop...
| Auteurs principaux: | , , , , , , , , |
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| Format: | Journal article |
| Publié: |
National Academy of Sciences
2019
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