The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression

<p><strong>Objectives</strong> To identify the functional basis for the genetic association of single nucleotide polymorphisms (SNP), upstream of the RUNX3 promoter, with ankylosing spondylitis (AS).</p> <p><strong>Methods</strong> We performed conditional...

书目详细资料
Main Authors:	Vecellio, M, Roberts, AR, Cohen, CJ, Cortes, A, Knight, JC, Bowness, P, Wordsworth, BP
格式:	Journal article
语言:	English
出版:	BMJ Publishing Group 2015

相似书籍

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
由: Vecellio, M, et al.
出版: (2019)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
由: Cohen, CJ, et al.
出版: (2022)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
由: Vecellio, M, et al.
出版: (2014)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
由: Vecellio, M, et al.
出版: (2021)

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism
由: Vecellio, M, et al.
出版: (2018)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
由: Vecellio, ML, et al.
出版: (2016)

Perspectives on the genetic associations of ankylosing spondylitis
由: Wordsworth, BP, et al.
出版: (2021)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
由: Appleton, LH, et al.
出版: (2016)

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
由: Roberts, AR, et al.
出版: (2016)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
由: Roberts, AR, et al.
出版: (2016)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
由: B. Paul Wordsworth, et al.
出版: (2021-03-01)

Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
由: Vecellio, M, et al.
出版: (2016)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
由: Roberts, A, et al.
出版: (2014)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
由: Roberts, A, et al.
出版: (2017)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
由: Connor Davidson, et al.
出版: (2023-01-01)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
由: Wordsworth, B, et al.
出版: (2017)

A CCR6 variant strongly associated with rheumatoid arthritis in two populations is not associated with ankylosing spondylitis
由: Cohen, CJ, et al.
出版: (2012)

The immunology of Ankylosing Spondylitis
由: Bowness, P
出版: (2011)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
由: Holden, W, et al.
出版: (2003)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
由: Cohen, C, et al.
出版: (2013)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
由: Bowness, P
出版: (2012)

The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis
由: Watts, L, et al.
出版: (2018)

Genetics of ankylosing spondylitis.
由: Brown, M, et al.
出版: (2002)

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
由: Brown, AC, et al.
出版: (2023)

ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations
由: Roberts, A, et al.
出版: (2017)

AN INVESTIGATION INTO NECK PAIN, CLINICAL AND FUNCTIONAL INDICES, AND DRIVING IN ANKYLOSING SPONDYLITIS
由: Holden, W, et al.
出版: (2002)

ANKYLOSING-SPONDYLITIS AND FUNCTIONAL ABILITY
由: Wordsworth, B, et al.
出版: (1984)

Hypophosphataemia masquerading as ankylosing spondylitis
由: Wordsworth, B, et al.
出版: (2008)

Susceptibility to ankylosing spondylitis.
由: Carter, N, et al.
出版: (2000)

The association of a common functional polymorphism in the tumour necrosis factor receptor 1 gene (TNFRSF1A) and disease severity in ankylosing spondylitis
由: Watts, L, et al.
出版: (2016)

Genetic susceptibility to ankylosing spondylitis.
由: Sims, A, et al.
出版: (2004)

ERAP1 and ankylosing spondylitis.
由: Keidel, S, et al.
出版: (2013)

No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis.
由: McCappin, J, et al.
出版: (2010)

Secretor status and ankylosing spondylitis.
由: Pal, A, et al.
出版: (1998)

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety.
由: Holden, W, et al.
出版: (2005)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
由: Timms, A, et al.
出版: (2003)

MicroRNAs in ankylosing spondylitis: Function, potential and challenges
由: Francesca Motta, et al.
出版: (2020-01-01)

New developments in our understanding of Ankylosing Spondylitis pathogenesis
由: Voruganti, A, et al.
出版: (2020)

COEXISTENT TOPHACEOUS GOUT AND ANKYLOSING-SPONDYLITIS
由: Portek, I, et al.
出版: (1983)

Progress in our understanding of the pathogenesis of ankylosing spondylitis
由: Simone, D, et al.
出版: (2018)