Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery

Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery

Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β-lactam hydrolysis. Combinations of a β-lactam antibiotic with an SBL inhibitor have been clinically successful; however,...

Полное описание

Библиографические подробности
Главные авторы:	Yang, Y, Yan, Y-H, Schofield, CJ, McNally, A, Zong, Z, Li, G-B
Формат:	Journal article
Язык:	English
Опубликовано:	Cell Press 2023

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