Viruses transfer the antiviral second messenger cGAMP between cells

Viruses transfer the antiviral second messenger cGAMP between cells

Cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA during virus infection and induces an antiviral state. cGAS signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING). We show that cGAMP is incorporated into viral particles, includ...

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Bibliographic Details
Main Authors:	Bridgeman, A, Maelfait, J, Davenne, T, Partridge, T, Peng, Y, Mayer, A, Dong, T, Kaever, V, Borrow, P, Rehwinkel, J
Format:	Journal article
Language:	English
Published:	American Association for the Advancement of Science 2015

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