Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications

Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications

The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of small-molecule ligands for proteins. To investigate the impact of stereo- and regiochemistry on ligand discovery, we synthesized a DNA-encoded library of 670,752 derivatives based on 2-azido-3-iodophenylpropion...

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Những tác giả chính: Favalli, N, Bassi, G, Pellegrino, C, Millul, J, De Luca, R, Cazzamalli, S, Yang, S, Trenner, A, Mozaffari, NL, Myburgh, R, Moroglu, M, Conway, SJ, Sartori, AA, Manz, MG, Lerner, RA, Vogt, PK, Scheuermann, J, Neri, D
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Nature Research 2021

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